Besides these basic parameters, three cases of CNR, i.e., ρ=10 dB, ρ=20 dB, and ρ=30 dB are considered.
Where M, P, and K vary with N, i.e., M=N/2, P=N, and K=⌈N/20⌉, three cases of CNR, i.e., ρ=10 dB, ρ=20 dB, and ρ=30 dB are, respectively, considered.
In Fig. 6, M, P, and K vary according to the varying N is simulated, where M=N/2, P=N, K=⌈N/10⌉, α=0.9, and three cases of CNR (i.e., ρ=30 dB, ρ=40 dB, and ρ=50 dB) are considered.
Reads per bin (RPB i) for each sample were computed and the CN ratio (CNR i) for each bin was calculated as CNR i = RPB i/Median RPB), where i stands for individual bins.
Amplification uniformity was assessed by the distribution of copy-number (CN) ratios (CNR i) of 6,000 "equal-read" bins across the genome (Baslan et al., 2012).
CNR i was further normalized based on the GC content of each bin (GC i) to yield the GC-normalized CN ratios (nCNR i).
The average CNR of user i is denoted by.
exponential random variables with CNR ¯ = E CNR j, i ( k ).
In 2014, a meta-analysis of four randomized phase-III trials (EORTC 22921, I-CNR-RT, PROCTOR-SCRIPT, CHRONICLE) failed to demonstrate any statistical efficacy of fluorouracil (5FU -based ACT.
Moreover, the definition of the limit of detectability of lesions (i.e., CNR > 8) is a complex function depending on the size and shape of the lesion.
To maintain a noise floor of 110 dB below the carrier power, i.e., CNR, a minimum carrier power is required.
