Sentence examples for cmtc in from inspiring English sources

For comparison purposes, we also tabulated the sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and accuracy of CMTC in predicting pCR together with the other gene signatures (Table S8 in Additional file 11).

Interestingly, we observed that the PAM50 subtype appeared to be more comparable to CMTC both in the internal training cohort [ 4] and in the internal validation cohort than the classical molecular classification: most normal-like and luminal A subtypes were found in the CMTC-1 group; most luminal B were found in the CMTC-2 group; and HER2 and basal-like were found in the CMTC-3 group.

Once we have validated the CMTC system in prospective clinical trials, we plan to introduce it into the clinic to help physicians guide treatment decision-making.

In this study, this oncogenic pathway pattern in CMTC classes was clearly reproduced in the second internal cohort: the highest activities in oncogenic pathways Myc, E2F1, Ras and β-catenin were seen again in the CMTC-3 group, with the worst outcome, as shown in the original study.

To examine the biological processes that may be involved in CMTC, oncogenic signaling pathway analyses were performed in the training cohort, which showed that CMTC-3 tumors had the highest activity in Her2 and other oncogenic signaling pathways (Myc, E2F1, β-catenin, Ras and IFN-γ) and the lowest activity in ER, PR and wild-type p53 pathways.

We observed the same pattern of clinical outcome among the CMTC groups (better in CMTC-1 and worse in CMTC-2 and CMTC-3) across all three platforms.

However, when we divided the 756 ER+ patients into the three CMTC groups, patients in CMTC-1 group had good clinical outcomes in general, particularly in the 115 patients treated with ET compared to the 184 untreated patients.

In the CMTC, the gene expression pattern of CMTC-1 is completely opposite that of CMTC-3 and results in a distinct, intermediate CMTC-2.

In CMTC, HER2+ and TN (similar to basal-like subtype) were grouped together in CMTC-3, and most normal-like and luminal A subtypes were grouped together in CMTC-1.

In a pairwise analysis, ER, PR and wild-type p53 pathways had the highest correlation with CMTC-1; in contrast, Myc, E2F1, Ras and β-catenin pathways were closely related to CMTC-3 in both internal cohorts.

This portfolio of pathway activities was completely opposite to that of CMTC-1, in which the breast cancer patients had a better prognosis.