Free fibular graft from contralateral leg in the presence of extensive dissections, especially if it is resected for more than 12 cm, may lead to fracture and failure of incorporation of graft and, even if it survives, will take a very long time to heal with poor functional outcome [7, 15].
In addition, lesions larger than 4 cm may lead to perforation, or gastrointestinal bleeding due to ulceration of the lesion [ 1, 2, 4, 5].
CM has been associated with a high intake of abortive medications with estimated analgesic overuse in 50 80% of patients with CM that may lead to the development of medication overuse headache (MOH) [47].
Second, since a considerable portion of CM-users were unable to provide full information about their CM formulae, it may lead to an underestimation of individual CMs associated with clinical outcomes.
BACKGROUND: Idiopathic intracranial hypertension (IIH) when no underlying etiology is found, is a clinical syndrome characterized by elevated intracranial pressure (ICP) (>25 cm H2O), which may lead to headaches and visual symptoms.
Since the selection of patients with schizoaffective disorder was based on ICD-9-CM codes, any coding inaccuracies may lead to misclassification of patients.
Ligation or removal of the shunt may lead to resolution of CM-I [ 5].
It is estimated that around 50 80 % of patients with CM referring to headache clinics show analgesic overuse that may lead to the development of medication overuse headache (MOH) [7].
Increased attack frequency may lead to the so-called 'chronic migraine' (CM), which becomes less responsive to both acute and prophylactic treatments.
Neuronal cell death by apoptosis during CM could then be a potential source of autoantigens that may lead to stimulation of the autoimmune responses [63].
