Sentence examples for cms generated from from inspiring English sources

These electrophysiological characteristics were subsequently observed in iPSC-derived CMs generated from a patient with equivalent SCN5A1795insD/+ mutation.

In order to minimize the possible differences from HCM iPSC clones, CMs generated from the two iPSC clones were utilized for sequencing.

However, it was not possible to determine accurately by immunofluorescence whether CMs generated from the LQT2-hPSCsN996I models presented any differences in subcellular localization of HERG channels when compared to their wild-type or corrected counterparts.

Most importantly, our data provide evidence that the pathogenesis of the N996I-HERG mutation can be modelled exclusively in CMs generated from hPSCs, without the need for heterologous and/or overexpression systems.

76 Human iPSC-derived CMs generated from two patients with TS (LQT8) showed irregular contractions, excessive Ca2+ influx, and markedly prolonged AP duration (three times longer than that of the wild-type control), 77 irregular electrical activity and abnormal intracellular Ca2+ transients associated with delayed inactivation of Cav1.2.

Substituting (L_c=0.1) m into Eq. (5), i.e., the approximate threshold size of the TLE catalogue, the number of objects larger than 10 cm generated from the collision can be estimated.

Finally, detailed understanding of the Ca2+-handling properties of hiPSC-CMs generated from healthy individuals may be used as a future reference when studying E-C coupling in hiPSC-CMs derived from patients with genetic disorders involving Ca2+-handling.

All experiments were performed in quadruplicates with EPC-CM generated from five different EPC donors.

In the other, CM, generated from an equivalent number of fibroblasts, was placed in the lower well of the invasion assay.

Let us first consider the two most recent studies that describe the phenotype of hiPSC-CM generated from patients with HCM.

Compared to hiPSC-CM generated from three unaffected family members, hiPSC-CM generated from four carriers of the TnT mutation all exhibited more disorganized sarcomere ultrastructure, reduced contractility by atomic force microscopy (AFM) and impaired SR Ca handling, all of which are hallmarks of myocytes isolated from explanted hearts from DCM patients (Table  1 ).