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The second patient was a 44 year old male with a 7 cm high grade sarcoma (histologically not otherwise specified, FNCLCC grade 3) at the lower lateral thigh.
Advanced neoplasia is defined as a lesion having one or more of the following characteristics: size ≥1 cm, high grade dysplasia, >25% villous histology, or invasive carcinoma.
Radiation therapy is typically considered for tumors with aggressive features (such as size ≥5 cm, high grade, and positive margins after surgery) and adjuvant chemotherapy may also be considered, particularly for younger patients with these features.
In brief, high risk was defined as tumor size >5 cm, high grade (grade II/III according to the Federation Nationales des Centres de Lutte Contre le Cancer (FNCLCC)), deep or extracompartimental localisation, local relapse or inadequate previous therapy.
Cluster 2 is composed of tumors with a high risk of relapse and progression (multiplicity, bigger size than 3 cm, high grade, and high stage) but with no relapse (or a very late superficial relapse) and no evidence of progression during a long follow-up period (almost 8 years).
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The one patient with subsequent IBTR was originally diagnosed at age 44 with a 0.2 cm high-grade DCIS tumor with comedonecrosis, margins ≥0.5 cm, and ER and PR negative (HER2/neu not tested).
For example, according to the St. Gallen risk classification, patients with N− tumors that are large (>2 cm), high-grade (histologic and/or nuclear grades 2 and 3), or show evidence of peritumoral vascular invasion are considered intermediate risk [ 19].
Polyp assessment was done per patient and in total for both groups, and included the number of all polyps, adenomas, and high-risk adenomas defined as size >1 cm, high-grade dysplasia, or villous component.
In E5194 the 10-year LR rate among cases with low- or intermediate-grade DCIS and tumor size ≤ 2.5 cm was 14.6 and 19.0 % for those with small (≤1 cm) high-grade DCIS [ 39].
Cases were further classified into multiple distal colorectal adenoma (two or more adenoma) and advanced adenoma (size of ⩾1 cm, high-grade dysplasia, or villous components, including tubulovillous); with some individuals falling into both categories.
In classic FAP, prophylactic colectomy is usually recommended, when polyposis is profuse or "worrisome" polyps are identified (ie, >1 cm, ulcerated, high grade dysplasia).
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