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This might have affected the number and size of the co-occurrence clusters we observed, but potentially has a minor effect on our analysis of Symbiodinium community composition because of the large unevenness and robust scaling behavior of the community.
Among these uniquely shared gene clusters, we observed a statistically significant enrichment of genes that belong to the COG category "cell wall/membrane/envelope biogenesis" (99% confidence interval) as well as "signal transduction mechanisms" (90% confidence interval) and "function unknown" (93% confidence interval) (Fig. 4).
Similarly, it is difficult to compare the positions of clusters reported on rice chromosomes 3, 6, and 9 with the positions of the QTL clusters we observed on the same chromosomes.
Although the rate of recovery from desensitization and the number of channels in the patch both contribute to the overall frequency of clusters, we observed no striking change in this parameter for the mutants.
When directly comparing cells in clusters, we observed an increased immunofluoresence for the adherens junction markers E-cadherin, APC and β-catenin in MRP-knockdown cells at sites of cell-cell contact (Fig. 4b).
In the case of the generally affected clusters, we observed several GO groups related to mechanical and/or energetic stress.
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These ultra-distant clusters display star-formation rates far greater than the clusters we observe today.
Across all clusters, we observe a trend towards an increased content of CNS towards the anterior end.
Thus, most positional gene clusters we observe are likely not composed of genes with similar biological functions.
The properties of the species clusters we observe will be determined by the diversification of those strains sharing the speciation loci (i.e those that determine gene flow).
In medulloblastoma cell lines (DAOY and UW228) engineered to express miR-520g, a biologically active constituent of the C19MC cluster, we observed reduced TF expression, procoagulant and TF signaling activities (responses to factor VIIa stimulation), and diminished TF emission as cargo of extracellular vesicles.
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Justyna Jupowicz-Kozak
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