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Finally, I will briefly describe the discovery of a black hole X-ray source in one of the globular clusters we identified in the Virgo elliptical galaxy NGC 4472.
In the SM clusters we identified all TH-GAL4 positive neurons, which belonged to four different types.
When comparing mutation clusters to results from dN/dS-based methods, we found that approximately 20% of the clusters we identified coincided with regions with dN/dS>1, while the remainder did not.
In addition to HOX gene clusters, we identified methylation in the promoter CGIs of several protocadherin gene families, all of which are located at chromosome 5q21 (See Figure S6).
Finally, we investigated the occupancy of transcription factors into the clusters we identified.
These data suggest that the 3' UTR clusters we identified are piRNA clusters.
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Do the clusters we identify actually represent positive selection, or might they just reflect relaxed selective pressures?
By assigning reads to known gene clusters we identify hotspots of biomedically relevant biosynthetic diversity.
Over multiple iterations of clustering, we identified 2404 genes that have strong H3K27me3 binding at the promoter region of WT CD71+Ter119+ erythroblasts, which is virtually eliminated in CD71+Ter119+ erythroblasts lacking Mtf2 (Supplementary Table S1).
For each cluster, we identified genes belonging to known signaling and metabolic pathways including nine clusters that significantly overlapped known pathways (FDR≤0.05; listed in Table S4).
Within these graph-clusters, we identified 554 components that are predicted to represent highly divergent alleles of the same gene that can then be merged, 1,293 components that are predicted to represent alternative splicing events, and 158 components (pairs of duplicated contigs) that are predicted to represent duplicated genes.
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CEO of Professional Science Editing for Scientists @ prosciediting.com