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Most of the robust clusters relating to the modern branches of the economy are concentrated in the larger urban areas of Sweden, though in some cases, also in other larger regional urban centres.
Many down-regulated gene-sets map to metabolic processes, with clusters relating to functions such as phospholipid and steroid biosynthesis, metabolic cofactors, amino acid metabolism and oxidative metabolism (specifically, citric acid cycle, mitochondrion, electron transport chain).
This implies that our algorithm can identify more functionally coherent gene clusters relating to specific TFs.
were much more highly represented than clusters relating to development and reproduction (e.g., growth, structure sizing).
In the molecular function, the clusters relating to "binding" and "catalytic activity" were enriched (21,089 and 12,443, respectively).
In all three classifications, clusters relating to cellular activity (e.g., cellular process, metabolic process, cyclic binding, signaling, etc).
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"We need to begin collecting the genetic, imaging, physiologic, and cognitive data to see how all the data – not just the symptoms – cluster and how these clusters relate to treatment response," he said.
Figure 5 Candidates for gene clusters related to substrate recognition.
Using this threshold, we identified 14 candidate clusters related to TCS.
Combining these results and substrate specific proteins, we found substrate-specific gene clusters related to recognition of each substrate.
However, the interpretation of these graphs (how certain clusters relate to projects or groups) requires domain and organizational knowledge.
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