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The correlations, index of the same sources for the correlated elements, allow us to identify different clusters of parameters: the first one is due to NaCl particles, the second one to aluminosilicates and the last one to the compounds with calcium and other metal elements.
Therefore, steady-state concentrations of proteins depend on clusters of parameters rather than on individual parameter values.
Five clusters of parameters representative of gait patterns were identified according to the clustering algorithm: cluster 1 included 34 cycles (23.3% out of the cycles analyzed), cluster 2 included 33 cycles (22.6%), cluster 3 included 26 cycles (17.8%), cluster 4 included 22 cycles (15.1%), and cluster 5 included 31 cycles (21.2%) (Table 1).
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Similarly, clusters of parameter values for different species, different measurement conditions etc. can be identified.
A second cluster of parameters in F1 animals was correlated to increased testis weight, and included female gonad weight, endometrium height, CYP19/aromatase activity in the ovary, and plasma testosterone levels in males.
In order to have a cluster of parameters which is capable of describing the characteristics of the material flow, the waste material has to be categorised and structured in accordance with the key processes which are used to process the material flow.
Mathematically elegant methods of variance decomposition and sensitivity clustering of parameters revealed non-trivial biological outcomes.
Through sensitivity clustering of parameters (see Section Methods) we obtained a dendrogram where four clusters may be clearly distinguished (Fig. 4).
In developing such a definition for the Australian National Sub-acute and Non-acute Patient (AN-SNAP) Version 1 Casemix Classification, a cluster of parameters identified an episode as palliative, rather than simply diagnosis.
Thus, we studied parameters of inflammation and endothelial dysfunction in the Diabetes Control and Complications Trial (DCCT /Epidemiology of Diabetes Intervention and Complications (EDIC) cohort, a large well-characterized cohort of patients with type 1 diabetes, to determine which parameter or cluster of parameters are associated with the presence of nephropathy and macrovascular complications.
Currently, several longitudinal studies focusing on the very elderly, have started to reveal immune signatures or biomarkers of immune ageing consisting not of a single parameter, but a cluster of parameters increasingly recognized as an "immune risk profile" or IRP [ 25- 27].
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