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The designs which protect against model misspecification are clusters of observations about the points that would have been the design points for classical variance-minimizing designs.
We took into account the repeated structure of the measures and the hierarchical data structure (i.e., the fact that the segments and vessels were clusters of observations in the patients).
It is worth to mention that in classification studies, Correspondence analysis can be used as preliminary step to represent the observations in an orthologonal system, so that euclidean distances can be calculated to construct clusters of observations (as for example in [ 11, 25]).
This modeling approach has two potential advantages, a) it can increase the accuracy of the inferred relationships and precision of the parameter estimates, and b) it can help identify groups or clusters of observations that support particular (condition-dependent) models or mixture components.
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Details are presented in the Supplementary Information, and the list of parameters that are automatically estimated are (i) Distance distribution: this defines the clustering of observations observed within CpG islands, shores and deserts.
Four clusters of observation describe in more specific detail the transnational culture at KHCC.
In multisite human immunodeficiency virus (HIV) observational cohorts, clustering of observations often occurs within sites.
Assessment and analysis raise questions regarding blinding and clustering of observations.
Jittering was employed to better display the clustering of observations among specific combinations of SCS and MAIS.
Analyses were carried out using multilevel statistical models to allow for the clustering of observations within patients.
The efficiency loss due to varying cluster sizes in trials where treatments induce clustering of observations in one of the two treatment arms is examined.
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