Sentence examples for clusters of mutations from inspiring English sources

Clusters of mutations and the sequential addition of mutations found in cell pedigrees suggest epigenetic attributes of SHM.

We apply the algorithm to genomes of bacteria, fly, and mammals, and find several clusters of mutations in functionally important regions of proteins.

He developed a statistical method to identify such clusters of mutations, and identified several cases of strong clustering of mutations in a comparison of human and chimpanzee genes.

These regions were inferred by locating extreme changes in coverage (defined as one standard deviation below the average) combined with clusters of mutations concentrated in small regions.

Our method takes into account the increased variability of exposed residues relative to buried residues and finds clusters of mutations that are unlikely to have arisen by chance given their composition of buried and exposed residues.

But when we carried out genome-wide scans for clusters of mutations between pairs of species, we found numerous clusters that, upon closer inspection, appeared to be artifacts in one of the species.

Whereas the present study did not reveal novel mutational hotspots in kinases in glioblastoma, we did observe a strong clustering of mutations in genes belonging to the PI3K-AKT pathway.

The trouble, they report in the current issue of Nature, was that each separate cluster of mutations produced a dead receptor, no matter which one was chosen first.

A cluster of mutations in the presence of the drug usually indicates a plausible region of drug target interaction.

The single Loop 2 mutation is L188H which extends this cluster of mutations towards the C-terminus.

Positive selection for protein function can lead to multiple mutations within a small stretch of DNA, i.e., to a cluster of mutations.