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Linkage analysis involving high densities of markers, where clusters of markers are in linkage disequilibrium (LD), can lead to biased results [26].
Because the barley genetic map has clusters of markers with the same genetic map position, the order of some markers is unknown.
ALDH1A2) and identified several large clusters of markers that have been implicated in broad aspects of retinoic acid metabolism and/or function, or that have been shown to be regulated by retinoic acid in other systems.
We observed significant clusters of markers on the majority of the catfish linkage groups.
Each linkage group showed dense clusters of markers, indicating strong LD.
Low values indicate relatively even space between markers; high values indicate uneven spacing with clusters of markers separated by gaps.
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The maximum asymptotic LOD score with RB was located at a cluster of markers from rs4275668 to rs10777556 corresponding to 104.11cM (92.8Mb).
For both phenotypes, the maximum asymptotic LOD with RB was located at a cluster of markers from rs6138473 to rs2073077 corresponding to 54.76cM 24.96Mbb).
That was because clustering of markers was very stable with the large number of tumors (i.e., excluding a few tumors did not substantially influence results) while tumor classification by clustering analysis based on the 16 markers was not stable.
We have identified a cluster of markers in the region of PKNOX2 gene that are strongly associated with a composite addiction phenotype rather than with any single addiction type.
Clustering of markers, however, has not been described before.
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