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The lack of a systematic approach to the selection of genes within QTLs coupled with extensive breeding programmes to define relatively small intervals without taking into account clusters of interacting genes has contributed to this disappointing return.
They identified 12 different clusters of interacting genomic loci that could be distinguished by the epigenetic status of the loci.
These clusters of interacting genes suggest co-regulatory mechanisms and may therefore lead to the discovery and/or elucidation of possible novel Pi-responsive network.
Using our LAV-based approach, the view for functional clusters of interacting pancreatic cancer-related proteins was obtained in less than four hours.
In this manner, PROFESS was mined to generate the view kog_interacting_cancer_protein, functional clusters of interacting pancreatic cancer-related proteins using the SQL statement shown in Figure 5A.
In order to ensure that clusters of interacting residues are not split, we assign a high penalty for gap insertions in rows and columns containing a high number of interactions.
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While this group of proteins formed a rather independent cluster of interacting partners in Figure 4 (see cluster 3), the link to the signaling and DNA damage response clusters is clearly evidenced through the superoxide radical capturing SOD1 and SOD2 proteins.
Cluster analysis of interacting biomolecules is enabled by a plugin for the density-based cluster analysis DBSCAN (Endesfelder et al., 2013; Ester, 1996), which also facilitates noise removal (Fig. 1d, showing clustering of GaG-mEos2 data).
Subsequent addition of SAM to reduced samples resulted in a concomitant perturbation of the reduced cluster's axial signal, providing direct evidence that ThiH coordinated a site-differentiated cluster capable of interacting with SAM.
The WISH network method detects clusters of highly interacting SNPs.
Being driven by coverage, the algorithm is inherently biased towards clusters of "widely interacting" trans-factors.
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