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We identified 21 clusters of human paralogs, comprising 54 genes, with the same pattern of MEHEs (table 2).
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Number of paralogs: For each human gene, a list of human paralogs was obtained from Ensembl's BioMart.
For instance, while the highest number of human paralogs are on the chromosome pairs 1q/9q, 7q/17q, 2q/12q, 15q/18q, 1q/6q and 5q/15q [ 2], the CNE duplicates are mostly clustered throughout 2p/14q, 8p/10q and 18p/19p/20p.
The existing publications concerning the asymmetry of the evolution of human paralogs are also somewhat controversial.
Significant asymmetry was observed in the evolution of 18% pairs of human paralogs when a third paralog is used as an outgroup.
It is known that distribution of human paralog pairs along the axis of protein divergence between pair members forms two main peaks.
This approximation is different from that used by Vieira and Rozas (2011) who only consider clusters of OBP paralogs.
Using the human paralog list, we compared each fish homolog of a human UCNE to all human paralogs if there were any.
With increasing evolutionary age, human paralogs exhibit declines in (i) the frequency of intrachromosomal paralogs, and (ii) the proportion of complete duplicates.
Because the evolutionary dynamics of paralogs in large multigene families may differ markedly from those of paralogs comprising small gene families, we restricted our analyses to human paralogs belonging to families comprising five or less paralogs.
This analysis predicted 178 axolotl paralogs and 62 human paralogs.
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