Clusters of granule cells and a few Purkinje cells were dispersed within the distorted molecular layer.
For the total granule count, large clusters of bright granules were ignored: these accounted for ∼8% of all granules in both control and palmitate-treated cells.
Patients with FTLD and AD showed numerous intensely immunostained, HSP27-positive granules in the cytoplasm of pyramidal neurons of the cerebral cortex, along with diffuse clusters of similar granules within glial cells.
In all patients with FTLD and AD, there were numerous intensely immunostained, HSP27-positive granules in the cytoplasm of pyramidal neurons of the cerebral cortex, along with abundant diffuse clusters of similar granules within glial cells in both grey and white matter regions.
It is hypothesised that higher levels of substituents are present in the amorphous regions and periphery of clusters of starch granules.
At the fluorescence-microscope level they appear as irregular, punctate structures, which vary in size and shape, and when examined by electron microscopy they are seen as clusters of interchromatin granules.
Several to a dozen microtubules (depending on axon diameter) are also present, and occasionally clusters of glycogen granules are seen within axons or in glia.
Clusters of glycogen granules were also observed in aged animals but not in young ones (Fig. 3A,B,E,F, arrow heads).
CBs were very often localized to various parts of the nucleus close to the nuclear envelope or near clusters of interchromatin granules (IGs) (Fig. 5d).
In some control subjects similar (to AD and FTLD), although less intense, HSP27 changes were present in the cytoplasm of pyramidal neurons of the cerebral cortex, and again as diffuse clusters of similar granules within glial cells.
