When the gradient becomes too steep to allow phase locking (i.e. (a_{0} > 1)), two or more clusters of oscillators (frequency plateaus) tend to form that oscillate at different frequencies.
Computational analysis of the available E. coli genome and protein structure databases identified that high-frequency-usage codons are mainly associated with structural elements, such as alpha helices, whereas clusters of lower frequency usage codons are more likely to be associated with beta-strands, random coils, and structural domain boundaries [ 47].
Viral population structure was organized into a limited number of clusters that included the dominant variants combined with multiple clusters of low frequency variants.
This pattern is confirmed by the network (Bandelt et al. 1999) shown in Fig. 5b, which reveals two distinct clusters of high-frequency haplotypes separated by several steps.
Inbreeding can generate correlations between loci throughout the genome [ 37], but it cannot create clusters of high frequency derived alleles without the occurrence of other genetic events such as selection or migration [ 6].
In the presence of the M-current, the firing frequency distribution is bimodal (see Figures S10 and S11) with one cluster of firing frequencies in the theta regime and another cluster in the hyper-excitable regime.
Hierarchical cluster analysis of frequency of CN aberrations observed in different histotypes indicated a close relatedness between B3 and TCs.
Here, hierarchical clustering of duplicate frequencies and raw duplicate distributions, normalized to metagenome size (Additional file 1: Figure S3), suggest a pattern of three duplication groups.
Finally, we combined and contrasted the various approaches and data sets and examined the underlying substructure of the results using clustering of motif frequencies in the promoter sequences.
MAD identifies mosaic segments as clusters of B allele frequencies (BAFs) with a similar skew statistically unlikely to be from constitutive frequencies, where expected BAFs for AA, AB and BB genotypes correspond to 0.0, 0.5 and 1.0 allele frequency.
