In this data set (n = 53) no adult controls were available but infancy and late childhood/puberty clusters of development-related gene expression were defined including 549 genes (753 probe-sets, ANOVA, p < 0.01).
The evolutionary origin of the growth pathways associated with the clusters of development-related gene expression defined in this study dates back to insects in the case of the glucocorticoid receptor pathway [ 55] and in most cases extends back to the origins of multi-cellularity e.g. WNT, TGFB, VEGF and NOTCH pathways [ 56].
By the time Smith held her first "climate change discussion" with a cluster of development NGOs in January of this year, she had already met with oil companies on eight occasions.
We also found that miRNA family 396 may be important in the control of leaf development, with three members of the family collocating with clusters of leaf development QTL.
When I worked at the White House, one of the things I studied was "clusters" of economic development.
Modulated genes were grouped mainly into clusters of skeletal development, ossification and bone remodelling.
We included all nine in Tehri and selected a sample of the 57 blocks in Guntur by stratifying them into three clusters by level of development (low, medium and high), and drawing proportional samples from each cluster (3 blocks from the low, 5 from the medium, and 1 from the high development cluster).
The cluster of "embryonic development" (Fig. S1, Table 2) contained 11 genes, of which IPA could join 9 to each other in a network of sub-clusters in which SHH was the only downregulated gene and BMP4 had the highest score of the upregulated (Fig. S2).
Since we see such a marked decrease in the abundance of mRNAs within this cluster of reproductive development genes, it may be possible that the processing of mRNAs into piRNAs is an underlying cause of the decline of maternally deposited mRNAs.
