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Despite this, we have identified 4 main clusters of concentration of these cytokines in SF suggesting the importance of identifying disease subgroups to personalize treatment.
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In our current work we found a high inter-individual variability in the levels of TNFalpha, IL-6, IL-15 and IL-15Ralpha in SF of RA patients and were identified four principal clusters of cytokines concentration in SF, suggesting the importance of identifying disease subset of patients for personalized treatment.
As expected, a greater number of clusters of high concentrations of candidate mate choice genes occur on the X chromosome than on the autosomes (Fig. 2; Table S3).
The envisaged goal of HBM studies, as stated in a 2005 summary report, is to establish baseline values and distributions of body burdens of environmental chemicals in the general population; foreseen next steps include identifying geographical clusters of elevated concentrations of biomarkers, studying time trends and evaluating the efficacy of regulatory action [ 5].
With regard to within-gender comparison, there were no GM differences between heterosexual and homosexual men, but heterosexual women showed clusters of increased GM concentration in comparison to homosexual women bilaterally in the temporo-basal cortex, ventral cerebellum, and left ventral premotor cortex.
Further, common economic- and market-driven innovative demands and goals of the trio have caused the emergence of clustering and concentration of experts in various fields.
The efficiency of photoluminescence propagation is investigated as a function of clusters concentration in the excitation area for several waveguides dimensions.
In contrast, two main clusters of higher CO2 concentrations (>580) are detected on the northern, northwestern, and western portion of the map, in the proximity of the main degassing fumarolic vents (crosses).
Figure 3 shows considerable clustering of lactate concentrations around 2.2 mM for this group.
Calculation of ICC confirmed this observation: we found significant clustering of CRP concentrations within districts (ICC = 2 %) but absence of within-district clustering of lymphocyte count (ICC = 0 %).
Additionally, we found that the significant clustering of CRP concentrations within districts (ICC = 2 %) disappeared after adjusting for PFOA and other covariates, corroborating the hypothesis that part of the CRP variation is explained by heterogeneous PFOA concentrations between districts.
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