Sentence examples for clusters of altered from inspiring English sources

Infancy and late childhood/puberty clusters of altered gene expression were observed in all tissue comparisons and overlap of gene expression (67 genes, Figure  6A & Additional file 1: Table S7) was used to generate an interactome model of 426 protein nodes and 447 connecting interactions.

This software highlighted the occurrence of clusters of altered data in a set of samples relatively to controls, using a moving data window to calculate an average log ratio value, while controlling the False Discovery Rate (FDR), according to user defined parameters.

Distinct clusters of altered lipids correlated with markers of inflammation (interferon-α and interleukin-6), microbial translocation (lipopolysaccharide (LPS) and LPS-binding protein), and hepatic function (bilirubin) (p<0.05).

RDS1 was also included in this group of genes because of the similar copy number variation profile within the analyzed strains, probably due to its location in the same cluster of altered ORFs as ADH7 and AAD3, in Chromosome III.

Large bF value for a duplicate cluster is indicative of altered functional constraints at many amino acid positions whereas bF ≈ 0 indicates that there was no significant shift in function from an ancestral function after gene duplication.

Very few transcripts were significantly regulated by the sub-toxic intake of 2 μg Se/g diet, but there were several clusters of transcripts altered significantly by 5 μg Se/g which were also variably affected by 2 μg Se/g diet.

Mice with an engineered deletion of the Snord116 repeat cluster (Snord116del) recapitulate the PWS phenotype of altered metabolism and growth deficiency, although not obesity (12, 13).

Clusters were then selected containing more than 90% of altered genes.

Further clustering of these altered genes according to their function revealed the significantly enriched pathways governing neuroplasticity and neurotoxicity/neurodegeneration (see Figure  2).

Functional annotation and clustering of significantly altered genes in either the MCF7 or MDA-MB-231 cell lines were analyzed using the DAVID Functional Analysis Tool (Fig.  1c, d) [ 35, 36].

The clustering of the altered amino acids in the y11, y11-2, and CD-5 mutants suggests that the affected residues are located in a domain critical for protein function.