The study, called M-FLU, conducted a randomized cluster intervention trial among students living in dorm housing.
The cluster intervention design can help to reduce both effects.
SPIRIT is a stepped wedge cluster intervention trial (figure 2) involving six agencies.
Models also included two cluster-level covariates, the geographic "density" of FSWs in each cluster (per square kilometer) and the time since the cluster intervention began.
After registering each participant, the system will notify the principal investigator of the allocation of the cluster (intervention or waiting list control).
Moreover, the nature of the cluster intervention means that on many occasions a component of the intervention is targeted at the residential home staff or at the healthcare professionals dedicated to the home.
The paediatric diabetes centre will be the unit of randomisation, cluster, intervention and analysis, because that is where the intervention is aimed, though the effect will be evaluated at the patient level.
If not possible due to the number or type of studies or heterogeneity, results were to be analysed using the clustered intervention approach (with clusters consisting of interventions, outcomes or elements) and/or in tabular format to aid interpretation [ 49].> The search retrieved 13,944 papers and a reference scan yielded 5 additional papers, as shown in the PRISMA flow diagram (Fig. 1) [ 50].
To discuss the importance of cancer symptom clusters in clinical practice, review evidence for symptom cluster interventions, and make recommendations for symptom cluster identification, patient education, and management in clinical practice.
We clustered interventions into four categories: prospective trial registration, incentives for reporting in peer-reviewed journals or research reports, public availability of individual patient-level data, and peer-review/editorial processes.
This community-based, two-arm cluster-randomized controlled trial will evaluate the impact of an EmONC package introduced by EmONC cluster teams in intervention clusters compared to standard care in control clusters.
