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Evidence for 14 homeobox gene clusters in human genome ancestry.
Application of a synthetic DNA G-quadruplex ligand as a genome-wide probe has provided evidence for G-quadruplex DNA clusters in human cells.
More to the point, a sub-network analysis was done to determine major functional clusters in human DRIN that govern key neurological pathways.
The protocadherin clusters in human and mouse contain two non-protocadherin genes (Slc25a2 and Taf7) located between the β and γ subclusters [2], [22].
High correlation between a human- and a mouse TSR indicates that these TSRs control identical gene clusters in human and mouse in the same way.
According to this model, boule was the ancestor gene that underwent the first gene duplication, generating autosomal dazl; dazl during primate evolution underwent the second gene duplication and chromosomal translocation to the Y chromosome, resulting in Daz; and two more Daz gene duplication produced the present-day Daz clusters in human.
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More than ten protein clusters are actually shared with pathways and protein clusters in humans.
These protein complex networks are regulated by 677 miRNAs and 154 known miRNA clusters in humans.
In addition, analyzing the complete repertoires of closely-related Ugt2 clusters in humans, mice, and rats revealed extensive lineage-specific duplications.
Two examples from the Homeobox (HOX) gene clusters in humans demonstrate the diversity of functions carried out by lncRNAs with regards to gene regulation.
In addition, analyzing the complete repertoires of closely-related Ugt2b clusters in humans, mice, and rats identified a new rat Ugt2b gene (designated Ugt2b39; Additional file 3) and revealed extensive lineage-specific duplications.
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