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Since the proposed method takes advantage of constant physical and geometrical properties of rigid clusters, improvement in the overall computational cost is observed comparing to the tradition application of fast multipole method.
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DOI: http://dx.doi.org/10.7554/eLife.02020.013 10.7554/eLiFigure20.014 figure 4—figure supplement 3. Simulated example illustrating the Clustering Improvement Factor.
We agree that the Clustering Improvement Factor (CIF) metric needed to be discussed in greater detail in the manuscript.
Finally the clustering improvement factor is novel and seems like an interesting metric proposed by the authors.
The Clustering Improvement Factor (CIF, fold better clustering than random expectation) estimate for each of the syndromes is shown along the periphery.
(A ) Clustering Improvement Factor (CIF) estimates are plotted vs the number of individuals per syndrome grouping in the Gorlin collection or patients with similar genetic variant diagnoses.
However, to avoid biases introduced by training data size, we also assessed the improvements in clustering by measuring the search space reduction (hereafter referred to as the Clustering Improvement Factor or CIF, 'Materials and methods').
We went on to develop an estimate of search space reduction, hereafter referred to Clustering Improvement Factor (CIF), to determine the improvements in clustering in Clinical Face Phenotype Space controlling for the composition of the database (a simulated example is provided in Figure 4 figure supplement 3).
There were improvements in all except two indicators in the program, and all clusters showed improvement in three indicators.
The addition of N2 together with TMS causes a slight increase of sp2 ring clusters and improvement of the mechanical properties probably due to the formation of SiN bonds.
As practices become larger, and work more closely with neighbouring practices and hospitals through federations and clusters, 23 improvement initiatives such as the one described in this study are likely to reap greater benefits for patients.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com