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Most samples were clearly assigned to one of the three clusters (assignment higher than 80%).
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Membership coefficients for individuals with posterior probabilities less than 0.05 were disregarded and proportionally assigned to the other cluster assignment coefficients.
Indeed, the overlap between FF and FFPE cluster assignment when excluding samples that are assigned to Cluster 0 is 86% (n=42/49).
Fig. 5 Score and cluster assignment.
Algorithm 2 is proposed to do clustering assignment.
Initially, the compounds are highlighted according to their cluster assignment.
In addition, it further introduces new strategy for clustering assignment.
Mathematically, the cluster assignment problem can be described as follows.
Fast support vector clustering (FSVC) [8] an equilibrium-based approach for clustering assignment.
Our proposed clustering assignment procedure is different with the existing procedure proposed in [1].
In Algorithm 2, the task of clustering assignment is reduced to itself for M equilibrium point.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com