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In yeast, humans and other eukaryotes, the clusters are assembled and incorporated into their target proteins by a group of assembly factors called the CIA machinery.
These clusters are assembled in mitochondria [22] by a complex series of chaperones and enzymes including ISCU, then exported to the cytoplasm, where they are assembled into the relevant protein [23].
The initial clusters are assembled to generate consensus sequences using CAP3.
In any case, there is now substantial evidence that the paradigm that Fe-S clusters are assembled or initiated solely in mitochondria is not true in mammalian cells, an issue that must be clarified to allow insights into disease pathophysiology.
Thus, the model that Fe-S clusters are assembled solely in mitochondria of yeast cells lacks crucial experimental support, and some models based on work in S. cerevisiae must be reconsidered.
Although the human and yeast Fe−S cluster biogenesis pathways share many components, the mechanisms by which cytosolic and nuclear Fe−S clusters are assembled appear to differ significantly.
Similar(52)
Four of the hydrophone clusters were assembled with the hydrophones pointing upward, referred to as "standard", while one cluster was assembled with the hydrophones looking downwards.
The former case is analogous to the Au clusters being assembled as lamellae and then rolled up as Au micro- and nano-tubes [12].
This compilation of nebulae and star clusters was assembled by the Danish-Irish astronomer John Dreyer based primarily on the observations of English astronomer John Herschel.
EST clusters were assembled using CAP3 [29] to form consensus sequences.
Clusters were assembled between 13000 and 14000 Da, the expected size of venom toxins.
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