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However, when we examined the genomic location of QTL clusters and genes identified by using natural variation, we found that the QTL clusters often contained multiple genes identified by using natural variation (Figure 3).
They do not include those assemblies, clusters, and genes not implicated in alternative splicing.
R loci are usually organized in clusters, and genes within one cluster are mostly derived from a common ancestor [ 4].
A Fisher's exact test was used to measure associations between the Clusters and genes regulated by AML1-ETO.
piPipes next assigns reads to different genomic features (e.g., transposons, piRNA clusters and genes) by their coordinates.
Most frequently R genes are arranged in clusters, and genes within one cluster are mostly derived from a common ancestral gene [ 4].
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To examine the relationship between gene clusters and gene function, the distribution of HOPACH clusters into functional categories was evaluated.
This robust relationship between gene clusters and gene functions indicates a coordinate regulation of cellular pathways at the transcriptional level.
Namely, that SPANX-N3 was the original locus, and duplication of this chromosomal segment eventually produced gene clusters and gene subfamilies.
Gene clusters and gene set enrichment.
In contrast, the plastome is structurally conserved with intact gene clusters, and gene order, indicating low recombination rates.
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