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Gene clusters and gene set enrichment.
To examine the relationship between gene clusters and gene function, the distribution of HOPACH clusters into functional categories was evaluated.
This robust relationship between gene clusters and gene functions indicates a coordinate regulation of cellular pathways at the transcriptional level.
One caveat may be that, without detailed geographical and time information in those sequences, the clusters and gene sequences can not be matched exactly.
Namely, that SPANX-N3 was the original locus, and duplication of this chromosomal segment eventually produced gene clusters and gene subfamilies.
In contrast, the plastome is structurally conserved with intact gene clusters, and gene order, indicating low recombination rates.
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Motivation: Gene clustering and gene set-based functional analysis are widely used for the analysis of expression profiles.
However, when we examined the genomic location of QTL clusters and genes identified by using natural variation, we found that the QTL clusters often contained multiple genes identified by using natural variation (Figure 3).
Probesets targeting individual exons can be further grouped into 'transcript clusters' and gene-level expression estimates can be obtained by considering all probes comprising a transcript cluster.
They do not include those assemblies, clusters, and genes not implicated in alternative splicing.
R loci are usually organized in clusters, and genes within one cluster are mostly derived from a common ancestor [ 4].
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