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To compensate for clustering of study subjects, we weighted these community-level data by the proportion of the census blocks included in a community-specific bounding rectangle that contained 95% of local study subjects (Tatalovich et al. 2006).
All outcomes will be analyzed using random effects models accounting for clustering of subjects within physicians' practices.
To account for the clustering of subject-level observations, parameters and standard errors were estimated robustly using a generalized estimating equation approach.
Of these, 5 IPD-MA seemed to ignore clustering of subjects by study completely, and pooled all subjects together.
The clustering of subjects is performed on logarithms of a set of 231 marker genes (identified in [ 7]).
§This term measures if the clustering of subjects in households is relevant to quantify the risk of ILI infection.
The expression of the statistically significant genes reliably reproduced the dose response clustering of subjects by arsenic exposure level.
Confidence intervals (CIs) for prevalence were calculated using jackknife methods and adjusted for clustering of subjects by village (15).
For the unsupervised hierarchical clustering of subjects based on gene expression, genes with average expression among all samples <5 FPKM were excluded.
Variables were autoscaled to unit variance before entering them into the PCA model, and clustering of subjects were displayed in a score-loading plot.
To further assess the clustering of subjects within these groups and across the groups, hierarchical clustering was performed in a comparison of the control and LVL groups and of the control and HVL groups.
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