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> The succession and clustering of interventions that we see in at least four cases (pathway b) does not appear to be an isolated occurrence.
A multilevel Poisson regression model was applied to estimate Incidence Rate Ratios (IRR) with 95% Confidence Intervals (CI) for A/T surgery among children aged 2 9 years in 2004 2006, while taking into account clustering of interventions within the 21 Local Health Units.
A random-intercept Poisson regression model was applied to estimate Incidence Rate Ratios (IRR) with 95% confidence Intervals (CI) for A/T surgery associated with age, sex, and citizenship (Italian and non-Italian), while taking into account clustering of interventions within Local Health Units.
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Because of concurrent interventions like these, it is not clear whether the decision support interventions alone or the cluster of interventions were responsible for the effect.
Because the set of interventions were not mutually exclusive, we have not reported on a full set of incremental comparisons for the cluster of interventions relating to cardiovascular disease.
According to the Health Council of The Netherlands, 'preconception care' (henceforth PCC) refers to the large cluster of interventions "aimed at ensuring that couples who wish to have children start a pregnancy under the best possible conditions" [ 1].
Incremental cost effectiveness ratios are also provided for each cluster of interventions, which give the additional cost needed to secure one extra healthy life year as successively less cost effective strategies are entered into the mix.
If not possible due to the number or type of studies or heterogeneity, results were to be analysed using the clustered intervention approach (with clusters consisting of interventions, outcomes or elements) and/or in tabular format to aid interpretation [ 49].> The search retrieved 13,944 papers and a reference scan yielded 5 additional papers, as shown in the PRISMA flow diagram (Fig. 1) [ 50].
The cluster of intervention, and thus the unit of randomisation, was the commune and its corresponding health station.
Fig. 8 Probability ranking plot of monthly migraine headache days, headache frequency and at least 50% reduction in migraine attacks Fig. 9 Probability ranking plot of all adverse events, nausea, dizziness and somnolence Fig. 10 Probability ranking plot of all-cause withdrawal and withdrawal due to AEs Fig. 11 Clustering of migraine interventions.
Randomised controlled trials (RCTs) and cluster RCTs of interventions comparing NPs and MDs will be included.
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