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Furthermore, the clustering of interaction profiles demonstrates protein-compound interactions can be separated into four Homopharma groups.
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Specifically, our data suggest that high values of nestedness, connectivity and clustering of interactions with mutualistic pollinators are beneficial to individual plants coexisting in local populations.
Active chromatin hubs (ACH) refer to the clustering of interactions between promoters and regulatory elements involved in the regulation of many tissue-specific genes [53].
The algorithm based on link communities performs a hierarchical clustering of interactions and considers a module to be a set of closely interrelated interactions.
This algorithm performs a hierarchical clustering of interactions, that is, instead of assuming that a functional module is a set of nodes with many interactions between them, it considers a module to be a set of closely interrelated interactions.
DOI: http://dx.doi.org/10.7554/eLife.02557.019 This clustering of interactions matches with the position of a previously mapped boundary between 'topological associated domains' (TADs; Dixon et al., 2012; Nora et al., 2012).
To select one potential complex out of five structures, we utilized an additional phylogenetic approach based on maximum likelihood analysis to highlight clusters of interaction "hot spots" on both DDX3X and CRM-1 surface.
Particularly in Figure 3(a), three clusters of interaction motifs are found.
At the center of the network, a tight cluster of interaction between hydrolase, ATPase and transmembrane transport activity is depicted.
The primary findings are: (i) some configurations that appeared to be uncoupled by linear spectral analysis metrics were actually found to be nonlinearly coupled, and (ii) two types of nonlinear coupling were observed one dominated by the fundamental and its interaction with higher modes, and another that displayed clusters of interactions between a frequency component and its sidebands.
We define two clusters of interactions; the first being characterised by two proteins with a shared domain which is not sufficient for maintaining the interaction.
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