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The apparent clustering of human cases of influenza A (H5N1) among blood relatives has been considered as evidence of genetic variation in susceptibility.
Clustering of human cases in time and space has important public health implications for understanding risk factors and sources of infection.
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Health officials in Indonesia continued to investigate a family cluster of human cases of avian influenza in Kubu Sembilang, a village in northern Sumatra where at least six of seven family members have died of the disease, the most recent on Monday.
A7 SCIENCE/HEALTH Europe on Alert for Bird Flu Health officials in Europe said they were on "high alert" as a third Turkish child was confirmed to have bird flu and more than two dozen people were under observation at a hospital, an unusual cluster of human cases that raises the possibility that the virus has become more contagious.
In the 1995 1996 cluster of human cases, all clinical isolates were susceptible to penicillin, several cephalosporins, clindamycin, erythromycin, and co-trimoxazole (MICs 0.25 µg/mL); all nine patients were treated with parenteral beta-lactam antibiotics and recovered uneventfully.
Since 1999 the poultry industry in Pakistan has also experienced sporadic infection with H7N3 and H5N1 highly pathogenic avian influenza (HPAI) viruses [18] including the cross-species transmission of H5N1 viruses to humans in late 2007, thought to have led to a family cluster of human cases [19].
Screening of travelers departing from areas where clusters of human cases are occurring.
It was concluded that these animals were not the main source of the large cluster of human cases.
Such high rates can explain how clusters of human cases are likely to result from substantial exposure to infectious aerosols.
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