Clustering caused by such systematic measurement error can result in bias and, in multicenter studies, will substantially reduce study power.
However, there are still open issues on how to solve problems related to the computation and communication overheads incurred by re-clustering caused by the stochastic nature of UEs.
To be included studies had to use multilevel data at least two levels including one or more region variable(s); address sample clustering caused by multilevel data structure; adjust for age, sex, and individual socioeconomic status; and be peer reviewed.
This indicated that the fluorophore density was roughly consistent on all diffraction-limited length scales (i. e., >200 nm) and that clustering caused no large CTxB or FcεRI-IgE density differences within the time scale of these measurements.
It is also useful to detect clustering caused by differences in the populations seen by physicians (e.g. local referral patterns), since it is not possible to build a generalizable prediction model when such heterogeneity is too large.
We cannot therefore entirely eliminate the possibility that each patch fortuitously included several IP3Rs and that their clustering caused τo to fall from ~10 ms to ~5 ms as we reported previously [ 40].
However, we found that lrrk loss-of-function does not phenocopy the lysosome clustering caused by expression of a constitutively active form of rab7 (rab7CA) (supplementary material Fig. S5B), as would be expected according to this model.
