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To test whether late endosomal DRMs are sensitive to cholesterol affecting drugs, an important criterion for being a raft-like domain [4], we treated late endosomes with either the cholesterol clustering agent saponin [53], [54] or the cholesterol binding compound filipin [38].
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Note that the x-axis is Nck concentration in panel A but total SH3 domain concentration in panel B. DOI: http://dx.doi.org/10.7554/eLife.04123.014 10.7554/eLiFigure23.015 Figure 4 figure supplement 1. Di-valent molecules are stronger clustering agents than mono-valent molecules.
In this case, the higher their proliferation rate the more rapidly will these cancer cells be eradicated by extra-centrosomes de-clustering agents.
From a distance, the cluster of many agents will be presented by a single agent (cluster agent) with an area surrounding him/her.
Note that in order to simulate a large number of agents, we have introduced the idea of the cluster agent.
Self-Organizing Map (SOM) clustering technique which finds homogeneous sub-series clusters was also linked to MI for proper cluster agent choice to be imposed into the models for predicting the nitrate loads of the watershed's sub-basins.
Each cluster agent ({rm{CA}}_{i}) is responsible to apply successively to each cluster ({rm {CL}}_{i}) a local search technique which is the tabu search algorithm to guide the research in promising regions of the search space and to improve the quality of the final population of the genetic algorithm.
The proposed algorithm builds on clustering the agents, MDP products construction and controller policies design.
Secondly, hydrogen market segmentation is studied by clustering involved agents in: lay people ('demand'), automobile salesmen ('supply') and experts.
In this case, the agent density will drop and eventually either the agents cluster or most agents will be isolated from one another.
end{aligned} (8) Open image in new window Fig. 8 Distribution of the cluster agents in the different clusters of the search space.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com