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Compiling genetic, molecular and clinical features of patients, these can be clustered into subgroups allowing more informed decisions about treatments.
Personalized-medicine-based clustering approaches, wherein patients are clustered into subgroups using statistical clustering heuristics, cannot escape this multiplicity issue either.
With this technique objects are grouped or clustered into subgroups of objects that resemble each other more than they resemble other objects outside these subgroups.
An analysis of promoter similarity indicated that co-expressed genes after SST treatment were clustered into subgroups, depending on the temporal expression patterns.
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No strains in this study were clustered into subgroup 2 with representative strain CH-1a, the earliest Chinese strain.
All the other strains were clustered into subgroup 3, which contained most Chinese strains collected later than 2004.
Group 3, namely late responsive group, contained 149 TFs that were clustered into subgroup 9 and 10.
Three genes JL1101, HB1103, and GZ1101 were clustered into subgroup 1 with the representative strains VR-2332 and BJ-4, and no strains in this study were clustered into subgroup 2 with the representative strains CH-1a, HB-1 sh)/2002, HB-1 sh2(sh)/2002.
Author's response: E2F and RB family protein sequences from fly and worm usually diverged highly and could not be clustered into subgroup in phylogenetic analysis based on protein sequences.
Three strains JL1101, HB1103, and GZ1101 were in subgroup 1 with the representative strains VR-2332, BJ-4, and CH-1a, and the SD1003 was the only strain clustered in subgroup 2 with the representative strain MN184A; all other 115 strains were clustered into subgroup 3 with multiple branches, which were completely composed of Chinese strains with the representative JXwn06 and HB-1 sh)/2002. HB-1 sh
The PCA also gives the opportunity to multivariately investigate how subjects cluster into subgroups and how certain subgroups differ.
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