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Indeed as suspected, many Sox2 binding sites already form clustered arrays along the linear chromosome (Whyte et al., 2013).
The array clustering groups did not consistently correspond with either PM resistance or WAA resistance, with closely clustered arrays often including F1 individuals with contrasting phenotypes for PM and WAA resistance.
Recent analyses find 239 functional V1R genes [ 10], 121 functional V2R genes [ 11] and 7 FPR genes (of which 5 are expressed in the VNO [ 19, 20]) distributed across the mouse genome in tightly clustered arrays.
This concept was described for the nucleolus, which assembles around NORs, stable nucleolar precursors, comprised of clustered arrays (i.e. multivalency) of the genes for rRNA, bound to the transcription factor UBF [ 71].
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Visualization of this clustered array led to the observation of several interesting regions.
Two-Dimensional hierarchical clustering analysis (2-D), using Cluster and TreeView softwares that employ a hierarchical clustering approach based on Pearson's correlation coefficient and PCA techniques were used to evaluate whether differentially expressed genes cluster arrays into groups (PTD and term delivery groups) [ 31, 32].
The 3 replicated arrays hybridized with the same mRNA clustered together (arrays 33, 34, 35).
Of particular importance is the observation that most UCRs are clustered into arrays that span hundreds of kilobases around their presumptive target genes.
There are thousands of images in the exhibition, each one unframed, even the many vintage prints on show, and pinned directly to the wall in grids, clusters, arrays, cinematic runs and groups.
There is another approach for obtaining dense cluster arrays.
RHEED has allowed as to carry our in-situ explorations of forming cluster arrays.
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