Sentence examples for cluster targeting from inspiring English sources

Moreover, the high similarity in genetic elements across disparate secondary metabolite biosynthetic pathways renders imprecise current gene cluster targeting strategies and contributes sequence complexity resulting in partial genome coverage.

Additionally, the multitude of NRPS and PKS derived natural products in L. bouillonii are predicted to have highly similar genetic elements in their biosynthetic gene clusters, and hence, gene cluster targeting efforts are imprecise and can often result in the isolation of the incorrect pathway (Fig. S3).

In particular, the lack of a functional miR290 cluster targeting Rbl2 in embryonic stem (ES) cells deficient for Dicer1 results in elevated levels of Rbl2 (Sinkkonen et al, 2008; Benetti et al, 2008a).

Class 1B miRNAs miR-17-92 miR-17-92 miR-17-923 and Ezh2 with significlusterrichmentargetss of >2.

On angiogenic VEGF stimulation, the miR-17 92 miR-17 92argets PTEN to promote endothelial proliferation.

Further work showed that miR-15a/miR-16-1 clusthe targets the anti-apoptotic BCL-2 (Cimmino et al, 2005).

Recent evidence showed that some protein complexes are enriched with single miRNA targets and some complexes are enriched with miRNA cluster targets [ 24].

We experimentally verified that the miR-141-200c clustargetsgets different components of the CtBP/ZEB complex, suggesting a potential orchestrated regulation in epithelial to mesenchymal transition.

The authors showed that several miRNAs from the miR17~92 cluster targeted DNMT-1 expression resulting in a negative feedback loop [ 28].

Initially, clusters targeting the smallest administrative units in Ethiopia called 'Kebele' were selected using simple random sampling after obtaining the list from the district administration.

When combined with bioinformatic analysis of putative natural product gene clusters, targeted screening and isolation can be performed on a prioritized list of strains.