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DBSCAN was implemented to cluster potential binding sites locally within protein targets for the Pilot dataset.
The effect of an arbitrary cluster potential is incorporated into the analysis by a variation of parameters procedure.
We report, for the first time, symmetric (versus cluster potential of zero charge) charging of narrowly dispersed monolayer-protected Au145 cluster films in a room temperature ionic liquid.
Based on the mobility requirements, we can cluster potential WLAN users into five groups: WLAN users who rarely move; hotspot users with laptops; typical office users with laptops; users of tablet PCs, personal digital assistants, or barcode scanners; and any users with Wireless Voice over Internet Protocol (WvolP) phones.
The combined V96P and N142M mutations in E. coli (VP/NM) decreased the cluster potential by 100 mV.
Combining the M153N mutation with the E. coli Loop 1 replacement (Loop 1/MN) in the B. taurus protein increased the cluster potential by 156 mV.
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The wild-type cluster potentials differ by 140 mV.
To test the effects of specific residues, mutations were generated in the B. taurus, Y. lipolytica and E. coli subunits and their cluster potentials were measured.
Names for the four clusters (Potential Activist, Environmental, Neutral, and National Interest) were based on inspection and interpretation of the mean responses to the clustering variables.
We developed a method for clustering potential binding sites using a curated dataset of structures for six therapeutically relevant proteins from diverse protein classes in the protein data bank.
The underlying benefit of this 'apoE-free' analysis is that it reveals the sample-clustering potential of other gel features, which was previously obscured by the inclusion of apoE-containing gel features.
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