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Despite the expected high variability, a very similar cluster organisation was found in all the three clones.
We found that RIFIN sequences (5ups, cds and 3dwn) show a very similar cluster organisation in the three examined clones.
3D7 was used as a reference; homologs in the other two clones were identified and then represented on the MDS plane according the cluster organisation established for 3D7.
This MDS analysis has established that RIFIN gene sequences maintain a very similar cluster organisation in all three of the examined genomes.
Gene clusters observed in s2 and i2_o2 species can be considered the less evolved stages of cluster organisation; compare Panels A – C.
In HB3 and Dd2 only few outliers were removed (5 sequences in HB3 and 12 Dd2) and MDS showed the same cluster organisation obtained in 3D7 (figure 3, panels B and C).
Similar(48)
The clustered organisation of the GiMAP loci in coral parallels the situation in mammals and plants.
In the majority of species, Hox genes are further defined by their clustered organisation in the genome.
Their clustered organisation in the genome is a consequence of their origin from tandem gene duplications and is intimately associated with their expression during development.
These variations in clusters organisation could indicate an adaptation for each insect order of their miRNA gene contents possibly related to life history traits.
The clustered organisation of these genes in each organism suggests relatively recent lineage-specific duplications, and phylogenetic analyses are consistent with this hypothesis, sequences clustering primarily with others from the same or closely related species.
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