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We identified a cluster of variations associated with changes in both diastolic (rs1904694, rs7897633 and rs7905063) and systolic BP (rs3790261, rs434082 and rs11893826) consequent to salt load.
Detailed analysis of one of the newly identified genetic alterations (in the DNA region corresponding to product 3) revealed in APO-SUS rats a cluster of variations in the myosin 1b gene.
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A previous study reported familial clustering of variation over time in global DNA methylation using the LUMA assay (Bjornsson et al., 2008).
The best way to characterize these continental patterns (as discrete clusters of variation) is by examining them to a genomic scale, given that single locus could not necessarily capture the global genomic scenario.
However, the formative phase of the ANCHUL study provided a prevalence estimate of 48%% and between cluster coefficient of variation (k) for this variable was 0.22 [ 20].
Finally, we note that the apparent functional redundancy detected here did not seem to reflect concerted up-regulation of any single pathway, since a cluster analysis of variation in protein abundance across gels showed that the SFPs that were associated with a given phenotype did not generally tend to cluster together (Additional file 1: Figure S2).
Figure 7 Univariate clustering: coefficient of variation distribution.
As a result, within-person or within-cluster sources of variation were accounted for in the analysis.
A value of k -the between-cluster coefficient of variation – to be equal was estimated in the intervention and control groups.
Moreover, different environmental exposures that increase or decrease the likelihood of developing asthma interact with different clusters of genetic variations.
To characterize the basic properties of the clusters generated by ADMSC, the cluster number, cluster size, and coefficient of variation (CV) of cluster size are calculated.
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