Well-run cultural venues are ideal for this and that's why all our projects are essentially three-way partnerships between ourselves, a venue and the pupils of a cluster of target schools.
The battleship had been designated as the aim point for Able and was painted red, with white gun barrels and gunwales, to make her stand out in the central cluster of target ships.
In our computational approach we therefore identified several previously unknown combinations of different TFs regulating a cluster of target genes (table 2 and 3).
In order to include e g (t) in the cluster of target genes of tf, the initiation of expression of g must occur at the same or the immediately following time-point to that of tf.
Exchanging information above this bound causes unnecessary aggregation in clusters of targets and reduction in efficiency.
First, from our prior ligand cluster range of targets, users can build their own compound libraries guided by the ligand clusters of targets or target sets that they interest.
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The assay similarities revealed clusters of targets known to be similar (e.g., GPCRs), as well as varied or dissimilar targets.
Hierarchical clustering of targets significantly altered by HP1γ (526 targets), S83A-HP1γ (492 targets) or S83D-HP1γ (1,727 targets) overexpression demonstrated that gene networks modulated by HP1γ experienced deregulation in the presence of the Ser mutation, indicating dependence of these processes on regulation of Ser phosphorylation.
Combining the information on known experimentally inferred targets, obtained from sRNAMap, sRNATarbase, and primary literature, as well as clustering of targets into functional groups revealed several important pathways that most likely changed in ∆ybeY cells when they were exposed to HU.
a The histogram of ligand cluster size, b the target distribution of ligands and ligand clusters, c the ligand (cluster) distribution of targets, d the relationship between the average molecular weight of ligand clusters and the ligand cluster promiscuity, nodes are coloured by the number of the nearby nodes, i.e. node density Fig. 5 The ligand cluster number of HGNC gene family.
