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For most genes, transcription starts in a cluster of positions, with some positions favored over others.
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This method has been used to identify clusters of positions that statistically co vary with one another and therefore are likely to co evolve and to be functionally related [34].
Our analysis identified clusters of positions along the coding regions that may undergo a conserved evolutionary selection for strong or weak local folding maintained across different viral variants.
Analysis of enrichment of specific DENV genes with clusters of positions with a significant conservation of folding energy signals and distribution of these clusters over different genes can be found in Additional file 1.
After we extracted the coupling profiles of these perturbations to compose a new matrix for clustering (see Supporting Information Figure S7), we found a stable and self-consistent cluster of 10 positions, as shown in the Figure 4A.
Figure 8 uses the NHGRI GWAS Catalog data from the eight aforementioned phenotypes to expand on a cluster of closely positioned phenotypes.
'Finding common interest' reflected a cluster of issues positioned at the fulcrum of the preceding three clusters and the one immediately following, and thus suggested as closely linked to these other concerns.
By the onset of the first winter, biennial growth will be limited to a basal rosette of leaves - a circular cluster of leaves positioned near the soil.
Then, magnetic field ranges are obtained from clustering of measuring positions by K-Medians algorithm for detection of high emission levels.
This demonstrated again the existence of two different clusters of correlated positions in the catalytic domains of Ser/Thr PKs.
The determination of statistically significant clustering of polymorphic positions was done essentially as described by Croucher et al. (8 ).
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