One of the emerging issues around toxic hotspots are clusters of poorly regulated small-scale industries found in many countries.
There are clusters of poorly cohesive cells (C) with low nucleo-cytoplasmic ratio, abundant pale cytoplasm and pale, vacuolated background.
Similar cerebellar dysplastic changes classified as heterotaxias (clusters of poorly organized mixed cells) were identified in 14% of normal infants but in 83% of infants with trisomy of different chromosomes [ 92].
EBL was identified as a tumor with the exclusive presence of nests and clusters of poorly differentiated cells forming true multilayered ependymoblastic rosettes but lacking a neuropil-like matrix (Fig. 1d).
The prognostic value of poorly differentiated clusters was confirmed by two additional publications by the same group of authors 70, 71 and also by another group.
69 Future studies are needed to prove the originality of poorly differentiated clusters as a histological feature as well as a prognostic variable.
In 2012, Ueno et al 69 proposed a new grading system for CRC based upon the quantification of "poorly differentiated clusters".
Tumour EMT was graded into one of three histological categories on the basis of integrated assessment of poorly differentiated clusters and pro-EMT desmoplasia at the leading edge of the primary tumour (HistologyEMT).
The root of the resulting tree is located in the vicinity of the rice sequence Os03g26800, within a poorly resolved cluster of long branches outside the C-type group.
In the co-expression network analysis, we found a cluster of genes (many of them poorly studied so far) strongly connected to calcyon, which may help elucidate its role in the brain.
Three new clades containing FH2 domains of multiple organism have been recovered – namely two branches containing most (but not all) basidiomycete and zygomycete formins, a cluster containing the majority of ciliate formins, and a somewhat poorly supported cluster of adjacent branches containing exclusively stramenopile sequences.
