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In all groups studied, 13%% of all large plaques (>300 μm) were multicored, indicating that this population of plaques developed from more than one initial plaque or a cluster of plaques within the post-Methoxy-XO4 injection interval.
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A recent study proposed clustering of plaques as different mechanism of plaque growth [ 34].
Second, we also observed clusters of plaques within the population of new plaques.
Taken together, our results demonstrate the clustering of plaques and the subsequent merger of plaque clusters as a mechanism of large plaque formation.
We propose a multi-faceted clustering mechanism whereby new plaques can deposit close to existing plaques forming a cluster of small plaques.
Our data provide direct in vivo evidence that plaques can enlarge by forming clusters of multiple plaques, implying a mechanism whereby the development of large plaques is attributed in part to the clustering of pre-deposited and newly deposited plaques.
These clusters of newly developed plaques suggest that once a new plaque has formed, subsequent new plaques cluster in the vicinity of this original new plaque.
They come in clusters — accumulations of plaque in arteries lead to heart attacks but also can lead to strokes and predispose to Alzheimer's disease.
Another major finding is the demonstration of C9orf72 and ubiquilin-1 positivity in a cluster of dystrophic neurites in senile plaques in AD brains by using antibodies discriminating ubiquilin-1 from ubiquilin-2; these results warrant further studies into the role of ubiquilin in neurodegeneration.
Gap junctions form clusters (junctional plaques) of individual channels arranged in parallel in the junctional membrane of two adjacent cells.
MEMPHIS — Two bright metal signs long welcomed visitors here to the grassy bluffs overlooking the Mississippi River, near a cluster of Civil War cannons and historical plaques.
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