Known to-date mechanotransduction pathways involved in cell responses include MAPK and other kinases signaling pathways, gap-junctional intercellular communication, up-regulation and clustering of integrins, involvement of the COX-2/PGE2, iNOS/NO pathways and activation of ATI mechanoreceptor.
Instead, the temporal and spatial patterning of the leukemia cluster suggested involvement of an infectious disease (Francis et al. 2012).
A mechanism for ring cyclization encompassing both dAdo generation from the radical SAM Fe S cluster and involvement of the cobalamin cofactor has been proposed.
A cluster of normal nodes may suggest malignant involvement but asymmetry in the pelvis is common, making this sign less reliable[ 17].
We found enriched ATP binding and glutathione peroxidase-associated GO terms in the up-regulated cluster of differentially expressed ESTs suggesting the involvement of other detoxification genes such as ATP binding cassette (ABC) transporters and quenchers of reactive oxygen species (ROS), which is in agreement with other insect studies [ 34, 35].
To maximize the benefits of cluster involvement, companies must participate actively and establish a significant local presence.
Although the size of the redefined Aec2 region remains relatively large for identification of individual candidate SjS susceptibility genes, the genes residing within this subregion can be grouped into four functionally clustered sets, each suspected previously of involvement in SjS susceptibility.
In light of its ever-increasing importance and ever-widening regulatory roles, we review here the latest body of knowledge on the cluster's involvement in health and disease as well as provide a novel perspective on the full spectrum of protein-coding and non-coding transcripts that are likely regulated by its members.
Clustering implies involvement of environmental factor(s).
So far no familial clustering or involvement of LPD in any syndrome has been found, however genetic syndromes like leiomyomatosis of the esophagus (X-linked Alport syndrome, [ 10]) or genitourinary tract (multiple cutaneous and uterine leiomyomatosis, MCUL, [ 11]) are well known.
A cluster of pathologies?
