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Findings: Adolescents with the cluster of increased fatigue and sleep disturbances experienced more depressive symptoms and behavior changes.
A maximum of 50% was used because once the scanning window covers more than half the geographic region and/or time period, the likelihood no longer reflects a cluster of increased risk inside the scanning window (Kulldorff et al. [1998]).
Higher GM concentrations were most prominent in the left perirhinal cortex, resembling the larges cluster of increased GM concentration spanning ventrally from the collateral sulcus, to the rhinal sulcus at the ventral border of the entorhinal cortex and extending to the ventral margin of the amygdala (Fig. 1, Table 2).
One cluster of increased FA, in the right supramarginal gyrus region, was also detected.
Biomarkers in use from these pathways include FOXO1 within the VEGF pathway, as a prognostic marker in rhabdomyosarcoma (as a fusion gene with PAX3 [ 59]) and also shown to be highly expressed in the infancy cluster of increased gene expression (Additional file 1: Table S2).
However, of note, one study in particular that found increased insula activation (Karlsson et al. 2008) did not distinguish between anterior and posterior insula in reporting and discussing this finding, but the reported cluster of increased insula activation in fact fell within the right posterior insula rather than AIC.
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Starting around 4200 cal BP, eight distinct clusters of increased cumulated probability density functions of the 14C dates were observed, representing enhanced alluvial deposition and/or fluvial activity.
These authors did not elucidate the causes of this clustering of increased mortality but suggested that environmental pollution, occupational exposures and social factors could be involved.
Cerebrospinal fluid (CSF) analyses detected clusters of increased volume in the 22q11.2DS group that co-localized with many medial GM reductions and indicated lateral and fourth ventricle dilation.
Clusters of increased brain activation for twins scoring high on obsessive compulsive symptoms were noted in the right parietal cortex (Clusters F and G) and left cingulate cortex (Cluster H).
Clusters of increased BOLD activation as a function of TOT were found in TBI survivors, as compared with healthy controls, with main peaks in the IPL and PFC in the right hemisphere.
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