Similarly, other studies examining adverse events following orthopedic trauma do so using large clusters of complications, making it difficult to evaluate postoperative septicemia following these procedures.
Are there differences in the onset, diabetes duration, and clustering of complications between type 1 and type 2 diabetes?
Despite anonymous data acquisition, patient tracking remains possible for analysing specific events such as clusters of complications or unexpected severe events.
Analysis of the predefined clustering of complications showed that there was a significant difference in the subgroup of infection complications (SG: 13 complications versus CG: 26 complications, P = 0.023).
Analysis of clustering of complications showed that the number of infection complications in patients undergoing bowel surgery was significantly reduced (SG: 8 complications versus CG: 18 complication, P = 0.01).
The types and clustering of complications were predefined in the study protocol, as described in Additional file 1. Pre-defined postoperative complications for each patient (see Additional file 1) were recorded for up to 28 days after surgery from the patient record and by visiting patients on the ward by the investigators.
Family members of CCI patients experience a cluster of mental complications [e.g., major depression, complicated grief, acute and posttraumatic stress disorder (ASD/PTSD)] which have been referred to as post-intensive care syndrome family (PICS-F) [3].
Having a loved-one in the ICU is a traumatic experience for family members that can lead to a cluster of psychological complications, recently defined as post-intensive care family syndrome.
The major pathogenesis of T2DM is insulin resistance, which is the resistance of target tissues to insulin action, and has been suggested to play a key role in the cluster of diabetic complications including atherosclerosis, and diabetic nephropathy (DN) [ 2, 3].
Approximately 50% of HIV-infected people treated with cART develop a cluster of peripheral metabolic complications (MC) [ 9] that include traditional cardiovascular disease risk factors such as dyslipidemia [ 10- 12], peripheral insulin resistance [ 13- 15], elevated blood pressure [ 16] and abdominal adiposity [ 17]: all components of "the metabolic syndrome" [ 18].
A cluster of clinically avoidable conditions (complications of low birth weight/prematurity, intra-partum problems including birth asphyxia, and neonatal infections) contribute to the bulk of the neonatal mortality in India [ 2].
