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"After knee surgery in March 1987, when I was 54, I was prescribed the sleeping pill Halcion, a sedative hypnotic in the benzodiazepine class of medications that can induce a debilitating cluster of adverse effects … My own adverse reaction to Halcion … started when I began taking the drug and resolved promptly when, with the helpful intervention of my family doctor, I stopped".
Poverty is not merely income poverty; it typically includes a cluster of adverse factors.
However, during clinical trials, a series of cases was identified in which a cluster of adverse events characterized by post-injection delirium and/or excessive sedation was observed [ 3, 4].
The cluster of adverse events, particularly perforation and toxic death reminiscent of DPD deficiency may have been due to chance occurrence or may have been due to the toxicity of a dose intense regimen.
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A key paper showing the clustering of adverse outcomes in type 1 diabetes in individuals with CKD from the FinnDiane cohort.
This important study shows the clustering of adverse outcomes in type 2 diabetes in individuals with CKD from the NHANES cohort.
Adult GHD syndrome is associated with clustering of adverse cardiovascular (CV) risk factors such as abnormal body composition, dyslipidemia, insulin resistance and abnormal haemostatic factors.
The final number of clusters of adverse outcome events was determined empirically and confirmed clinically.
Multilevel models account for potential clustering of adverse perinatal outcomes within hospitals.
There was a clustering of adverse events in participants with a high MPA exposure, thus refining the therapeutic window.
In addition, the clustering of adverse metabolic characteristics and elevated hsCRP levels was independently associated with low SHBG levels.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com