In addition we have recently observed that the miR-18 cluster is over-expressed in a panel of samples from various cancers types [20].
Finally, the model shows that in the absence of N AND L this target gene cluster is over-expressed.
When the miR-99 cluster is over-expressed in irradiated cells, the rate and the overall efficiency of repair by both NHEJ and homologous recombination are reduced [ 30].
One cluster was over-expressed in MNA tumors, while the other was under-expressed.
Separate MDCK cell lines (derived by us from single-cell clones) were constructed in which either Zeb-1 or the miR-23a cluster was over-expressed.
This cluster was over-represented by GO terms, phosphate transport and response to external stimulus (that includes candidate genes FPR2 and S100A8).
The genes in this cluster are over-represented for those encoding proteins involved in interaction, metabolism, RNA processing, transcription, translation and cytoskeleton function.
This cluster was over-represented with many terms relating to control of gene transcription, as well as terms associated with regulation of metabolism and biological processes.
In addition the R2 (peak expression at tree ripe) sub-cluster is over-represented (compared with the other ripening sub-clusters, R1 and R3) in the "metabolism" category (25.4% vs 21.7 and 18.4%) correlating with changes in energy and metabolism during late ripening.
For the individual clustering a cut-off rc of 0.4 was used and the level of overclustering was set to 10 clusters, being over twice the expected number of clusters, similar to the procedure followed in the main analysis (Stage A: Individual clustering, step A2).
The nonobese group with clustering was over twice as likely to have PVD alone (2.36 [1.31–4.25]) and the obese group was three times more likely to have PVD alone (3.16 [1.73–5.75]) compared with the nonobese group without clustering.
