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Of 45 clusters investigated as part of the official cluster investigation study with patients eligible for interview, we interviewed all persons in 13 clusters.
This threshold detected all 43 outbreaks identified through routine laboratory surveillance during the study period and resulted in a cluster investigation positive predictive value (percentage of clusters investigated that were solved) of 13% (Table 3).
We present findings from the cluster investigation and results of a mass screening exercise.
We propose a novel bioinformatics solution for rectifying that limitation, ensuring the feasibility of WGS for cluster investigation.
DNA fingerprinting of Mycobacterium tuberculosis has a key role in TB control and cluster investigation as the molecular data obtained can be used to direct and focus public health control efforts [1], [2].
In 2,206 clustered cases, DNA fingerprinting increased the number of epidemiologic links from 462 before DNA fingerprinting data was known to 1,002 epidemiologic established links after cluster investigation involving a combination of molecular and epidemiological data.
Combining geographic and molecular data can enhance cluster investigation.
More than one third of the relationships were identified only after the DNA cluster investigation.
The scope of this cancer cluster investigation exceeded any previous study of pediatric leukemia.
However, cluster investigation must be incorporated into routine public health practice, including the standardization of protocols.
Further details about the formal cluster investigation study are provided elsewhere (9).
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CEO of Professional Science Editing for Scientists @ prosciediting.com