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In the subsequent discussion, we first briefly present our approaches for the fractal surface generation, the GFMD model, the contacting cluster detection algorithm, and the numerical experimental design.
The number of RyR clusters in the analysis volume was counted using a cluster detection algorithm [9] which showed a small but significant (P = 0.03, Student's t-test) reduction in the number of RyR clusters per unit volume of contractile apparatus in diseased myocytes (Figure 5F).
The cluster detection algorithm used, MCODE, relies on a major parameter called the "node score cutoff", which influences size of the detected clusters and their intra-connectivity.
Detail for the cluster detection algorithm and a definition of the discreteness is described in Supplementary Material (sections: Use of factor analysis to remove concatenation of different transcripts and and Factor Analysis for detection of regions having alternative isoforms).
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The inherent problems associated with low-diversity libraries described here will also apply to the latest Illumina sequencing platform, the HiSeq 2000, since it makes use of the same chemistry and cluster detection algorithms as GAII systems.
We implemented 2 cluster detection algorithms (CDA) into CP.
It may be useful for automating the testing and validation of spatial and temporal cluster detection algorithms.
The timely use of automated diagnosis information, especially with cluster detection algorithms, may be a valuable resource for supplementing current infectious disease surveillance systems.
For local perturbations, the reactions are chosen from one randomly selected cluster (identified by the cluster-detection algorithm above).
The number of Φ populations (Fig. 5A) was estimated statistically by using a cluster-detection algorithm (SKM), which assumes each population had a Gaussian distribution with an independent mean and s.d [5].
Specific components of the method, such as the scoring function or the cluster-detection algorithm, are easily interchangeable and can be adapted to the task at hand.
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