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The unique caspase-independent apoptosis model described here can give important clues to further research on how apoptogenic factors are released from mitochondria.
While the results presented here are expected to offer some clues to further study the viral infection mechanisms, we see a new trigger to induce cell death in the measles virus nucleoprotein which is amenable to re-engineering as a targeted molecule.
Metabolomic analysis will provide the next large set of clues to further our understanding of human health and disease.
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It provides another clue to further increase the production of isoprenol.
Such an assumption provides a clue to further study the diverse functionality of this enzyme family.
Although the efficacy of bosentan for dermal and pulmonary fibrotic conditions associated with SSc is limited, the present observation definitely provides us with a useful clue to further explore the potential of the upcoming new dual endothelin receptor antagonists with better clinical effects as disease-modifying drugs for SSc.
Although the efficacy of bosentan for dermal and pulmonary fibrosis is limited in SSc, the present observation definitely provides us with a useful clue to further explore the potential of the upcoming new dual endothelin receptor antagonists as disease modifying drugs for SSc.
Here, the challenges of pharmacophore modeling and applications in drug discovery are discussed and recent advances and latest developments are described, which provide useful clues to the further development and application of pharmacophore approaches.
Thus, PML-NBs may provide clues to the further pathogenesis of JC virus-induced demyelinating disease.
The hyperdense basilar artery sign is one of the earliest signs on non-contrast CT imaging and may be the only clue to guide further management in a patient with basilar artery occlusion.
Detecting an interaction subset should be acceptable since this gives a good "clue" to help further identify the complete interaction.
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